Open AccessHaplotype-Based Localization of an Alcohol Dependence Gene to the 5q34 γ-Aminobutyric Acid Type A Gene Cluster
Author(s) -
Marta Radel,
Roger L. Vallejo,
Nakao Iwata,
Richard Aragon,
Jeffrey C. Long,
Matti Virkkunen,
David Goldman
Publication year - 2005
Publication title -
archives of general psychiatry
Language(s) - English
Resource type - Journals
eISSN - 1538-3636
pISSN - 0003-990X
DOI - 10.1001/archpsyc.62.1.47
Subject(s) - linkage disequilibrium , genetics , locus (genetics) , haplotype , allele , biology , genetic linkage , alcohol dependence , gene cluster , gene , alcohol , biochemistry
Pharmacobehavioral and pharmacogenetic evidence links gamma-aminobutyric acid type A (GABA(A)) receptors and chromosomal regions containing GABA(A) receptor genes to ethanol-related responses. The GABA(A) gene cluster on chromosome 5q34 is of particular interest in the genetics of alcohol dependence because of the gamma2 subunit requirement for ethanol's modulatory action on GABA(A) receptors, previous linkage findings in mice and humans implicating both GABRA6 and GABRG2, and reported associations of GABRA6, GABRB2, and GABRG2 alleles with alcohol dependence.