Open AccessApolipoprotein E ϵ4 Count Affects Age at Onset of Alzheimer Disease,but Not Lifetime Susceptibility
Author(s) -
Ara S. Khachaturian
Publication year - 2004
Publication title -
archives of general psychiatry
Language(s) - English
Resource type - Journals
eISSN - 1538-3636
pISSN - 0003-990X
DOI - 10.1001/archpsyc.61.5.518
Subject(s) - apolipoprotein e , allele , incidence (geometry) , risk factor , demography , age of onset , genotype , cumulative incidence , alzheimer's disease , psychology , disease , genetics , medicine , gerontology , oncology , biology , gene , cohort , physics , sociology , optics
The incidence of Alzheimer disease (AD) increases strongly with age, but little is known about the cumulative incidence of AD over a lifetime of 100 years, or its relationship to the polymorphic APOE locus that encodes apolipoprotein E. APOE is a strong genetic risk factor for AD.
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