Measurement of Phosphorylated Tau Epitopes in the Differential Diagnosisof Alzheimer Disease
Author(s) -
Harald Hampel,
Katharina Büerger,
Raymond Zinkowski,
Stefan Teipel,
Alexander Goernitz,
Niels Andreasen,
Magnus Sjoegren,
John F. DeBernardis,
Daniel J. Kerkman,
Koichi Ishiguro,
Hideto Ohno,
Eugeen Vanmechelen,
Hugo Vanderstichele,
Cheryl McCulloch,
HansJürgen Möller,
Peter Davies,
Kaj Blennow
Publication year - 2004
Publication title -
archives of general psychiatry
Language(s) - English
Resource type - Journals
eISSN - 1538-3636
pISSN - 0003-990X
DOI - 10.1001/archpsyc.61.1.95
Subject(s) - dementia with lewy bodies , frontotemporal dementia , tau protein , dementia , alzheimer's disease , frontotemporal lobar degeneration , cerebrospinal fluid , vascular dementia , psychology , medicine , pathology , pathogenesis , endocrinology , disease
Abnormal hyperphosphorylation of the microtubule-associated protein tau and its incorporation into neurofibrillary tangles are major hallmarks of the pathogenesis of Alzheimer disease (AD). Different tau phosphoepitopes can be sensitively detected in cerebrospinal fluid (CSF).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom