Comparison of Progressive Cortical Gray Matter Loss in Childhood-OnsetSchizophrenia With That in Childhood-Onset Atypical Psychoses | Zendy

Nitin Gogtay | Zendy; Alexandra Sporn | Zendy; Liv Clasen | Zendy; Tom Nugent | Zendy; Deanna Greenstein | Zendy; Rob Nicolson | Zendy; Jay N. Giedd | Zendy; Marge Lenane | Zendy; Peter Gochman | Zendy; Alan C. Evans | Zendy; Judith L. Rapoport | Zendy

Open Access

Comparison of Progressive Cortical Gray Matter Loss in Childhood-OnsetSchizophrenia With That in Childhood-Onset Atypical Psychoses

Author(s) -

Nitin Gogtay,

Alexandra Sporn,

Liv Clasen,

Tom Nugent,

Deanna Greenstein,

Rob Nicolson,

Jay N. Giedd,

Marge Lenane,

Peter Gochman,

Alan C. Evans,

Judith L. Rapoport

Publication year - 2004

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.61.1.17

Subject(s) - psychosis , psychology , magnetic resonance imaging , analysis of variance , neuroimaging , audiology , post hoc analysis , schizophrenia (object oriented programming) , age of onset , pediatrics , medicine , psychiatry , radiology , disease

Recent anatomical brain magnetic resonance imaging (MRI) studies show a striking postpsychotic progressive loss of cortical gray matter (GM) in patients with childhood-onset schizophrenia (COS), which appears greater than that seen for adult patients. However, the diagnostic specificity and the relationship of these changes to drug treatment and cognitive functioning remain unclear. We performed a comparative prospective brain MRI study in patients with COS and pediatric patients with transient psychosis with behavior problems (psychosis not otherwise specified) provisionally considered multidimensionally impaired (MDI). We hypothesized that cortical GM loss would occur in patients with COS but not in adolescents with atypical psychoses.

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