The Heritability of Bipolar Affective Disorder and the Genetic Relationship to Unipolar Depression | Zendy

Peter McGuffin | Zendy; Frühling Rijsdijk | Zendy; Martin Andrew | Zendy; Pak C. Sham | Zendy; Randy Katz | Zendy; Alastair G. Cardno | Zendy

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The Heritability of Bipolar Affective Disorder and the Genetic Relationship to Unipolar Depression

Author(s) -

Peter McGuffin,

Frühling Rijsdijk,

Martin Andrew,

Pak C. Sham,

Randy Katz,

Alastair G. Cardno

Publication year - 2003

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.60.5.497

Subject(s) - mania , bipolar disorder , concordance , proband , heritability , twin study , genetic correlation , psychology , depression (economics) , research diagnostic criteria , genetic model , psychiatry , confidence interval , dizygotic twin , clinical psychology , medicine , genetics , schizophrenia (object oriented programming) , genetic variation , mood , biology , population , environmental health , macroeconomics , economics , mutation , gene

Twin studies of bipolar affective disorder (BPD) have either been small or have not used explicit diagnostic criteria. There has been little use of genetic model fitting and no analyses to explore the etiological overlap with unipolar depression (UPD).

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