Development of a New Once-a-Day Formulation of Methylphenidate for the Treatment of Attention-deficit/Hyperactivity Disorder | Zendy

James M. Swanson | Zendy; Suneel Gupta | Zendy; Andrew Lam | Zendy; Ira Shoulson | Zendy; Marc Lerner | Zendy; Nishit B. Modi | Zendy; Elizabeth Lindemulder | Zendy; Sharon B. Wigal | Zendy

Open Access

Development of a New Once-a-Day Formulation of Methylphenidate for the Treatment of Attention-deficit/Hyperactivity Disorder

Author(s) -

James M. Swanson,

Suneel Gupta,

Andrew Lam,

Ira Shoulson,

Marc Lerner,

Nishit B. Modi,

Elizabeth Lindemulder,

Sharon B. Wigal

Publication year - 2003

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.60.2.204

Subject(s) - methylphenidate , dosing , attention deficit hyperactivity disorder , tachyphylaxis , pharmacodynamics , pharmacokinetics , medicine , pharmacology , anesthesia , psychology , psychiatry

The duration of action of the immediate-release formulation of methylphenidate hydrochloride is short (3 to 4 hours), and 3 times daily dosing is thought to maximize effectiveness across a 12-hour day. The initial sustained-release formulations of methylphenidate had reduced efficacy compared with immediate-release methylphenidate and were not well accepted. Tachyphylaxis was hypothesized to account for the reduced effects, and an ascending drug delivery pattern was proposed to overcome this acute tolerance.

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