Familial Patterns of Risk in Very Late-Onset Alzheimer Disease | Zendy

Jeremy M. Silverman | Zendy; Christopher J. Smith | Zendy; Deborah B. Marin | Zendy; Richard C. Mohs | Zendy; Cathi B. Propper | Zendy

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Familial Patterns of Risk in Very Late-Onset Alzheimer Disease

Author(s) -

Jeremy M. Silverman,

Christopher J. Smith,

Deborah B. Marin,

Richard C. Mohs,

Cathi B. Propper

Publication year - 2003

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.60.2.190

Subject(s) - proband , age of onset , hazard ratio , family aggregation , medicine , cumulative incidence , incidence (geometry) , risk factor , disease , psychology , pediatrics , demography , confidence interval , cohort , genetics , biology , physics , sociology , gene , optics , mutation

The incidence of Alzheimer disease (AD) peaks after 85 years of age. Although genetic factors are implicated in AD with substantially earlier onset, the familial characteristics of high-incidence very late-onset AD (VLOAD, defined here as AD with onset age >/=85 years) remain unknown.

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