Alterations in Stress Cortisol Reactivity in Depressed Preschoolers Relative to Psychiatric and No-Disorder Comparison Groups | Zendy

Joan L. Luby | Zendy; Amy Heffelfinger | Zendy; Christine Mrakotsky | Zendy; Kathy Brown | Zendy; MARTHA J. HESSLER | Zendy; Edward L. Spitznagel | Zendy

Open Access

Alterations in Stress Cortisol Reactivity in Depressed Preschoolers Relative to Psychiatric and No-Disorder Comparison Groups

Author(s) -

Joan L. Luby,

Amy Heffelfinger,

Christine Mrakotsky,

Kathy Brown,

MARTHA J. HESSLER,

Edward L. Spitznagel

Publication year - 2003

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.60.12.1248

Subject(s) - psychology , stressor , psychosocial , reactivity (psychology) , major depressive disorder , analysis of variance , depression (economics) , clinical psychology , repeated measures design , maternal deprivation , hypothalamic–pituitary–adrenal axis , conduct disorder , psychiatry , developmental psychology , medicine , mood , hormone , statistics , alternative medicine , mathematics , pathology , economics , macroeconomics

Despite the robust and widely replicated finding of elevated hypothalamic-pituitary-adrenal (HPA) axis reactivity in depressed adults, studies of depressed children have yielded ambiguous findings. Animal models of early depression and studies of children experiencing early psychosocial deprivation have suggested that alterations in HPA axis reactivity are evident in early "depressive-like" conditions. The current study is, to our knowledge, the first investigation of HPA axis reactivity in very young children with a clinical depressive syndrome for which content validity has been established.

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