P300 and Genetic Risk for Schizophrenia | Zendy

Georg Winterer | Zendy; Michael Egan | Zendy; Thomas J. Raedler | Zendy; Carmen E. Sanchez | Zendy; Douglas W. Jones | Zendy; Richard Coppola | Zendy; Daniel R. Weinberger | Zendy

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P300 and Genetic Risk for Schizophrenia

Author(s) -

Georg Winterer,

Michael Egan,

Thomas J. Raedler,

Carmen E. Sanchez,

Douglas W. Jones,

Richard Coppola,

Daniel R. Weinberger

Publication year - 2003

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.60.11.1158

Subject(s) - temporoparietal junction , psychology , audiology , schizophrenia (object oriented programming) , psychosis , oddball paradigm , event related potential , neuroscience , electroencephalography , developmental psychology , psychiatry , cognition , medicine , prefrontal cortex

We assessed the suitability of event-related potential frontal and temporoparietal P300 changes as intermediate phenotypes in genetic studies of schizophrenia. We applied a principal component analysis approach based on the notion that P300 abnormalities in siblings of schizophrenic patients may involve a widespread network of relatively weak cortical generators and because an earlier, smaller study that used a topographic analysis of covariance model did not show that localized P300 changes predict risk for schizophrenia.

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