A Specific Deficit in Context Processing in the Unaffected Siblings of Patients With Schizophrenia | Zendy

Angus W. MacDonald | Zendy; Michael F. PogueGeile | Zendy; Melissa K. Johnson | Zendy; Cameron S. Carter | Zendy

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A Specific Deficit in Context Processing in the Unaffected Siblings of Patients With Schizophrenia

Author(s) -

Angus W. MacDonald,

Michael F. PogueGeile,

Melissa K. Johnson,

Cameron S. Carter

Publication year - 2003

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.60.1.57

Subject(s) - endophenotype , psychology , prefrontal cortex , context (archaeology) , schizophrenia (object oriented programming) , dorsolateral prefrontal cortex , neuroscience , dissociation (chemistry) , cognition , expectancy theory , psychosis , cognitive psychology , developmental psychology , audiology , psychiatry , medicine , biology , paleontology , social psychology , chemistry

Understanding the biological basis of complex, heritable illnesses such as schizophrenia is facilitated by sensitive and functionally specific measures of intermediate processes. Context processing is a theoretically motivated construct associated with executive function. Impairments in this process have been associated with dysfunction of the prefrontal cortex. In the present study, we evaluated whether a specific deficit in context processing could be associated with the unexpressed genetic liability to schizophrenia.

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