Association Between Smaller Left Posterior Superior Temporal Gyrus Volume on Magnetic Resonance Imaging and Smaller Left Temporal P300 Amplitude in First-Episode Schizophrenia | Zendy

Robert W. McCarley | Zendy; Dean F. Salisbury | Zendy; Yoshio Hirayasu | Zendy; Deborah YurgelunTodd | Zendy; Mauricio Tohen | Zendy; Carlos A. Zarate | Zendy; Ron Kikinis | Zendy; Ferenc A. Jólesz | Zendy; Martha E. Shenton | Zendy

Open Access

Association Between Smaller Left Posterior Superior Temporal Gyrus Volume on Magnetic Resonance Imaging and Smaller Left Temporal P300 Amplitude in First-Episode Schizophrenia

Author(s) -

Robert W. McCarley,

Dean F. Salisbury,

Yoshio Hirayasu,

Deborah YurgelunTodd,

Mauricio Tohen,

Carlos A. Zarate,

Ron Kikinis,

Ferenc A. Jólesz,

Martha E. Shenton

Publication year - 2002

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.59.4.321

Subject(s) - planum temporale , temporal lobe , psychosis , psychology , magnetic resonance imaging , superior temporal gyrus , temporal cortex , gyrus , audiology , neuroscience , medicine , psychiatry , functional magnetic resonance imaging , radiology , epilepsy

In chronic schizophrenia, the P300 is broadly reduced and shows a localized left temporal deficit specifically associated with reduced gray matter volume of the left posterior superior temporal gyrus (STG). In first-episode patients, a similar left temporal P300 deficit is present in schizophrenia, but not in affective psychosis. The present study investigated whether the left temporal P300-left posterior STG volume association is selectively present in first-episode schizophrenia.

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