Impact of Normal Sexual Dimorphisms on Sex Differences in Structural Brain Abnormalities in Schizophrenia Assessed by Magnetic Resonance Imaging
Author(s) -
Jill M. Goldstein,
Larry J. Seidman,
Liam M. O’Brien,
Nicholas J. Horton,
David N. Kennedy,
Nikos Makris,
Verne S. Caviness,
Stephen V. Faraone,
Ming T. Tsuang
Publication year - 2002
Publication title -
archives of general psychiatry
Language(s) - English
Resource type - Journals
eISSN - 1538-3636
pISSN - 0003-990X
DOI - 10.1001/archpsyc.59.2.154
Subject(s) - planum temporale , psychology , schizophrenia (object oriented programming) , neuroscience , supramarginal gyrus , cingulate cortex , psychosis , psychiatry , functional magnetic resonance imaging , central nervous system
Previous studies suggest that the impact of early insults predisposing to schizophrenia may have differential consequences by sex. We hypothesized that brain regions found to be structurally different in normal men and women (sexual dimorphisms) and abnormal in schizophrenia would show significant sex differences in brain abnormalities, particularly in the cortex, in schizophrenia.
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