Cytokine-Associated Emotional and Cognitive Disturbances in Humans | Zendy

Abraham Reichenberg | Zendy; Raz Yirmiya | Zendy; Andreas Schuld | Zendy; Thomas Kraus | Zendy; Monika Haack | Zendy; Abraham Morag | Zendy; Thomas Pollmächer | Zendy

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Cytokine-Associated Emotional and Cognitive Disturbances in Humans

Author(s) -

Abraham Reichenberg,

Raz Yirmiya,

Andreas Schuld,

Thomas Kraus,

Monika Haack,

Abraham Morag,

Thomas Pollmächer

Publication year - 2001

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.58.5.445

Subject(s) - cytokine , anxiety , heart rate , mood , medicine , psychology , mood disorders , receptor antagonist , endocrinology , antagonist , blood pressure , receptor , clinical psychology , psychiatry

Infectious, autoimmune, and neurodegenerative diseases are associated with profound psychological disturbances. Studies in animals clearly demonstrate that cytokines mediate illness-associated behavioral changes. However, the mechanisms underlying the respective psychological alterations in humans have not been established yet. Therefore, we investigated the effects of low-dose endotoxemia, a well-established and safe model of host-defense activation, on emotional, cognitive, immunological, and endocrine parameters.

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