Selective Deficits in Prefrontal Cortex Function in Medication-Naive Patients With Schizophrenia | Zendy

M Deanna | Zendy; Cameron S. Carter | Zendy; Todd S. Braver | Zendy; Fred W. Sabb | Zendy; Angus W. MacDonald | Zendy; Douglas C. Noll | Zendy; Jonathan D. Cohen | Zendy

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Selective Deficits in Prefrontal Cortex Function in Medication-Naive Patients With Schizophrenia

Author(s) -

M Deanna,

Cameron S. Carter,

Todd S. Braver,

Fred W. Sabb,

Angus W. MacDonald,

Douglas C. Noll,

Jonathan D. Cohen

Publication year - 2001

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.58.3.280

Subject(s) - dorsolateral prefrontal cortex , functional magnetic resonance imaging , psychology , context (archaeology) , schizophrenia (object oriented programming) , working memory , prefrontal cortex , neuroscience , dorsolateral , continuous performance task , audiology , medicine , psychiatry , cognition , paleontology , biology

Previously we proposed that dorsolateral prefrontal cortex (PFC) supports a specific working memory (WM) subcomponent: the ability to represent and maintain context information necessary to guide appropriate task behavior. By context, we mean prior task-relevant information represented in such a form that it supports selection of the appropriate behavioral response. Furthermore, we hypothesized that WM deficits in schizophrenia reflect impaired context processing due to a disturbance in dorsolateral PFC. We use functional magnetic resonance imaging to examine PFC activation in medication-naive, first-episode patients with schizophrenia during a WM, task-isolating context processing.

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