Modulation by Muscarinic Antagonists of the Response to Carbon Dioxide Challenge in Panic Disorder | Zendy

Marco Battaglia | Zendy; Silvana Bertella | Zendy; Anna Ogliari | Zendy; Laura Bellodi | Zendy; Enrico Smeraldi | Zendy

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Modulation by Muscarinic Antagonists of the Response to Carbon Dioxide Challenge in Panic Disorder

Author(s) -

Marco Battaglia,

Silvana Bertella,

Anna Ogliari,

Laura Bellodi,

Enrico Smeraldi

Publication year - 2001

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.58.2.114

Subject(s) - pirenzepine , muscarinic antagonist , panic disorder , muscarinic acetylcholine receptor , anesthesia , hypercapnia , hyperventilation , panic , psychology , medicine , anxiety , psychiatry , receptor , acidosis

Panic attacks can be induced in persons with panic disorder by inhalation of carbon dioxide. Hypercapnia also elicits a reflex hyperventilation, which is controlled in part by cholinergic mechanisms. This study investigated whether the exaggerated response to carbon dioxide in panic disorder (PD) can be modulated by antagonists of muscarinic cholinergic receptors.

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