Antipsychotics and the Risk of Sudden Cardiac Death | Zendy

Wayne A. Ray | Zendy; Sarah Meredith | Zendy; Purushottam B. Thapa | Zendy; Keith G. Meador | Zendy; Kathi Hall | Zendy; Katherine T. Murray | Zendy

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Antipsychotics and the Risk of Sudden Cardiac Death

Author(s) -

Wayne A. Ray,

Sarah Meredith,

Purushottam B. Thapa,

Keith G. Meador,

Kathi Hall,

Katherine T. Murray

Publication year - 2001

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.58.12.1161

Subject(s) - medicine , antipsychotic , confidence interval , risperidone , cohort , cohort study , relative risk , retrospective cohort study , confounding , sudden cardiac death , thioridazine , pediatrics , psychiatry , schizophrenia (object oriented programming) , chlorpromazine

Case reports link antipsychotic drugs with sudden cardiac deaths, which is consistent with dose-related electrophysiologic effects. Because this association has not been confirmed in controlled studies, we conducted a retrospective cohort study in Tennessee Medicaid enrollees, which included many antipsychotic users; there were also computer files describing medication use and comorbidity. The study was conducted before the introduction of risperidone and, thus, did not include the newer atypical agents.

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