Brain Serotonin2 Receptors in Major Depression | Zendy

Lakshmi N. Yatham | Zendy; Peter F. Liddle | Zendy; IShin Shiah | Zendy; Gayle Scarrow | Zendy; Raymond W. Lam | Zendy; Michael J. Adam | Zendy; Athanasios P. Zis | Zendy; Thomas J. Ruth | Zendy

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Brain Serotonin2 Receptors in Major Depression

Author(s) -

Lakshmi N. Yatham,

Peter F. Liddle,

IShin Shiah,

Gayle Scarrow,

Raymond W. Lam,

Michael J. Adam,

Athanasios P. Zis,

Thomas J. Ruth

Publication year - 2000

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.57.9.850

Subject(s) - statistical parametric mapping , binding potential , medicine , voxel , receptor , depression (economics) , cerebellum , positron emission tomography , endocrinology , correlation , nuclear medicine , psychology , chemistry , neuroscience , magnetic resonance imaging , radiology , macroeconomics , economics , geometry , mathematics

Postmortem and brain imaging studies that measured brain serotinin(2) (5-HT(2)) receptors in major depression reported an increase, decrease, and no change compared with controls. In this study, we assessed brain 5-HT(2) receptors in 20 depressed patients (mean +/- SD age, 40.1 +/- 9.5 years; range, 22-60 years) and 20 healthy controls similar in age (37.2 +/- 12.6 years; range, 19-59 years) using positron emission tomography and setoperone labeled with fluorine 18 ([(18)F]setoperone).

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