Reduced Dorsal and Orbital Prefrontal Gray Matter Volumes in Schizophrenia
Author(s) -
Raquel E. Gur,
Patricia E. Cowell,
Amanda Latshaw,
Bruce I. Turetsky,
Robert I. Grossman,
Steven E. Arnold,
Warren B. Bilker,
Ruben C. Gur
Publication year - 2000
Publication title -
archives of general psychiatry
Language(s) - English
Resource type - Journals
eISSN - 1538-3636
pISSN - 0003-990X
DOI - 10.1001/archpsyc.57.8.761
Subject(s) - psychology , dorsolateral prefrontal cortex , prefrontal cortex , neurocognitive , white matter , schizophrenia (object oriented programming) , magnetic resonance imaging , audiology , neuroscience , dorsolateral , cognition , psychiatry , medicine , radiology
Converging neuroanatomic, neurophysiological, and neurobehavioral evidence implicate prefrontal subregions in schizophrenia. Neuroanatomic studies with magnetic resonance (MR) imaging enable regional volume parcellation. Inconsistent reports may relate to variable methods and small samples. We attempted to resolve volume differences within sectors of the prefrontal lobe in a large sample, relating volumes to clinical and neurocognitive features.
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