Evidence of the Dual Mechanisms of Action of Venlafaxine | Zendy

Anne T. Harvey | Zendy; Richard L. Rudolph | Zendy; Sheldon Preskorn | Zendy

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Evidence of the Dual Mechanisms of Action of Venlafaxine

Author(s) -

Anne T. Harvey,

Richard L. Rudolph,

Sheldon Preskorn

Publication year - 2000

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.57.5.503

Subject(s) - maprotiline , venlafaxine , sertraline , pharmacology , venlafaxine hydrochloride , chemistry , tyramine , reuptake inhibitor , antidepressant , serotonin , endocrinology , medicine , biochemistry , receptor , hippocampus

Indirect evidence suggests that the antidepressant venlafaxine hydrochloride selectively inhibits serotonin (5-HT) uptake at low doses, whereas at high doses, it inhibits both 5-HT and norepinephrine (NE) uptake. We hypothesized that, in vivo, both high and low doses would inhibit the 5-HT uptake of platelets but that the higher dose would differentially blunt the pressor response to tyramine, a marker for NE uptake.

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