Decrease in Brain Serotonin 2 Receptor Binding in Patients With Major Depression Following Desipramine Treatment | Zendy

Lakshmi N. Yatham | Zendy; Peter F. Liddle | Zendy; Joelle Dennie | Zendy; IShin Shiah | Zendy; Michael J. Adam | Zendy; Carol J. Lane | Zendy; Raymond W. Lam | Zendy; Thomas J. Ruth | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Decrease in Brain Serotonin 2 Receptor Binding in Patients With Major Depression Following Desipramine Treatment

Author(s) -

Lakshmi N. Yatham,

Peter F. Liddle,

Joelle Dennie,

IShin Shiah,

Michael J. Adam,

Carol J. Lane,

Raymond W. Lam,

Thomas J. Ruth

Publication year - 1999

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.56.8.705

Subject(s) - desipramine , antidepressant , medicine , psychology , serotonin , 5 ht receptor , 5 ht2 receptor , receptor , endocrinology , pharmacology , hippocampus

The neuroreceptor changes involved in therapeutic efficacy of various antidepressants remain unclear. Preclinical studies have shown that long-term administration of various antidepressants causes down-regulation of brain serotonin 2 (5-HT2) receptors in rodents, but it is unknown if similar changes occur following antidepressant treatment in depressed patients. Our purpose, therefore, was to assess the effects of treatment with desipramine hydrochloride on brain 5-HT2 receptors in depressed patients using positron emission tomography (PET) and fluorine-18 (18F)-labeled setoperone.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research