Open AccessNaloxone Challenge in Smokers
Author(s) -
Suchitra KrishnanSarin,
Marc I. Rosen,
Stephanie S. O’Malley
Publication year - 1999
Publication title -
archives of general psychiatry
Language(s) - English
Resource type - Journals
eISSN - 1538-3636
pISSN - 0003-990X
DOI - 10.1001/archpsyc.56.7.663
Subject(s) - (+) naloxone , nicotine , craving , endogenous opioid , medicine , opioid , endocrinology , nicotine withdrawal , narcotic antagonist , opiate , antagonist , psychology , anesthesia , addiction , psychiatry , receptor
This study used an opioid antagonist challenge procedure to evaluate the responsivity of the endogenous opioid system in nicotine-dependent individuals, as evidenced by naloxone-induced alterations in both behavioral (withdrawal, craving) and neuroendocrine (cortisol levels) parameters.
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