Progressive Cortical Change During Adolescence in Childhood-Onset Schizophrenia | Zendy

Judith L. Rapoport | Zendy; Jay N. Giedd | Zendy; Jonathan D. Blumenthal | Zendy; Susan Hamburger | Zendy; Neal Jeffries | Zendy; Thomas Fernandez | Zendy; Rob Nicolson | Zendy; Jeffrey S. Bedwell | Zendy; Marge Lenane | Zendy; Alex Zijdenbos | Zendy; Tomáš Paus | Zendy; Alan C. Evans | Zendy

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Progressive Cortical Change During Adolescence in Childhood-Onset Schizophrenia

Author(s) -

Judith L. Rapoport,

Jay N. Giedd,

Jonathan D. Blumenthal,

Susan Hamburger,

Neal Jeffries,

Thomas Fernandez,

Rob Nicolson,

Jeffrey S. Bedwell,

Marge Lenane,

Alex Zijdenbos,

Tomáš Paus,

Alan C. Evans

Publication year - 1999

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.56.7.649

Subject(s) - white matter , psychology , psychosis , magnetic resonance imaging , schizophrenia (object oriented programming) , brain size , cerebrospinal fluid , neuroimaging , grey matter , neuroscience , medicine , psychiatry , radiology

Adolescence provides a window to examine regional and disease-specific late abnormal brain development in schizophrenia. Because previous data showed progressive brain ventricular enlargement for a group of adolescents with childhood-onset schizophrenia at 2-year follow-up, with no significant changes for healthy controls, we hypothesized that there would be a progressive decrease in volume in other brain tissue in these patients during adolescence.

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