Lack of Association Between Depression and Loss of Neurons in the Locus Coeruleus in Alzheimer Disease | Zendy

Witte J.G. Hoogendijk | Zendy; Iris E. Sommer | Zendy; Chris W. Pool | Zendy; Wouter Kamphorst | Zendy; Michel A. Hofman | Zendy; Piet Eikelenboom | Zendy; Dick F. Swaab | Zendy

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Lack of Association Between Depression and Loss of Neurons in the Locus Coeruleus in Alzheimer Disease

Author(s) -

Witte J.G. Hoogendijk,

Iris E. Sommer,

Chris W. Pool,

Wouter Kamphorst,

Michel A. Hofman,

Piet Eikelenboom,

Dick F. Swaab

Publication year - 1999

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.56.1.45

Subject(s) - locus coeruleus , depression (economics) , psychology , disease , alzheimer's disease , dementia , medicine , central nervous system disease , degenerative disease , locus (genetics) , psychiatry , neuroscience , central nervous system , biology , economics , macroeconomics , biochemistry , gene

Depression, one of the most frequent psychiatric disturbances in Alzheimer disease (AD), is proposed to have its neurobiological basis in neuron loss in the noradrenergic locus coeruleus, although this is not the case in idiopathic depression.

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