Decreased Brain GABAA-Benzodiazepine Receptor Binding in Panic Disorder | Zendy

Andrea L. Malizia | Zendy; Vincent J. Cunningham | Zendy; Caroline Bell | Zendy; Peter F. Liddle | Zendy; Terry Jones | Zendy; David J. Nutt | Zendy

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Decreased Brain GABAA-Benzodiazepine Receptor Binding in Panic Disorder

Author(s) -

Andrea L. Malizia,

Vincent J. Cunningham,

Caroline Bell,

Peter F. Liddle,

Terry Jones,

David J. Nutt

Publication year - 1998

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.55.8.715

Subject(s) - benzodiazepine , panic disorder , flumazenil , gabaa receptor , psychology , panic , radioligand , orbitofrontal cortex , psychosis , medicine , psychiatry , neuroscience , anxiety , endocrinology , receptor , prefrontal cortex , cognition

Positron emission tomography (PET) allows the measurement of benzodiazepine-gamma-aminobutyric acidA (GABA(A)) receptor kinetics. We employed flumazenil radiolabeled with carbon 11, a radioligand that labels the benzodiazepine site on the GABA(A) receptor, and fully quantitative, high-sensitivity PET to test the hypothesis that central benzodiazepine site binding is decreased in medication-free patients with panic disorder.

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