Use of Pattern Analysis to Predict Differential Relapse of Remitted Patients With Major Depression During 1 Year of Treatment With Fluoxetine or Placebo | Zendy

Jonathan W. Stewart | Zendy; Frederic M. Quitkin | Zendy; Patrick J. McGrath | Zendy; Jay D. Amsterdam | Zendy; Maurizio Fava | Zendy; Jan Fawcett | Zendy; Frederick W. Reimherr | Zendy; Jerrold F. Rosenbaum | Zendy; Charles M. Beasley | Zendy; Paul Roback | Zendy

Open Access

Use of Pattern Analysis to Predict Differential Relapse of Remitted Patients With Major Depression During 1 Year of Treatment With Fluoxetine or Placebo

Author(s) -

Jonathan W. Stewart,

Frederic M. Quitkin,

Patrick J. McGrath,

Jay D. Amsterdam,

Maurizio Fava,

Jan Fawcett,

Frederick W. Reimherr,

Jerrold F. Rosenbaum,

Charles M. Beasley,

Paul Roback

Publication year - 1998

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.55.4.334

Subject(s) - placebo , fluoxetine , placebo response , depression (economics) , medicine , rating scale , hamilton rating scale for depression , antidepressant , clinical trial , major depressive disorder , psychology , economics , macroeconomics , developmental psychology , receptor , alternative medicine , pathology , amygdala , hippocampus , serotonin

Delayed and persistent ("true drug") improvement characterizes the response to antidepressant medication. Early or nonpersistent ("placebo") benefit is typical of a placebo response. The prediction was that patients with a true drug response would sustain their benefit best if they continued to receive the drug and that patients with a placebo response would have an equivalent prognosis whether they continued to receive the drug or were switched to placebo.

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