Family History of Alcoholism and Hypothalamic Opioidergic Activity | Zendy

Gary S. Wand | Zendy; Deborah Mangold | Zendy; Samer El Deiry | Zendy; Mary E. McCaul | Zendy; Donald R. Hoover | Zendy

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Family History of Alcoholism and Hypothalamic Opioidergic Activity

Author(s) -

Gary S. Wand,

Deborah Mangold,

Samer El Deiry,

Mary E. McCaul,

Donald R. Hoover

Publication year - 1998

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.55.12.1114

Subject(s) - opioidergic , endogenous opioid , offspring , medicine , endocrinology , naloxone hydrochloride , (+) naloxone , family history , opioid receptor , opioid antagonist , opioid , psychology , receptor , pregnancy , biology , genetics

This study was designed to assess whether nonalcoholic offspring from families with a high density of alcohol-dependent individuals have altered endogenous central nervous system opioid activity. Naloxone hydrochloride stimulates plasma cortisol by blocking opioidergic input on the corticotropin-releasing factor neuron, thereby providing a noninvasive method for measuring hypothalamic opioid tone.

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