Open AccessCost Analysis of Enteroviral Polymerase Chain Reaction in Infants With Fever and Cerebrospinal Fluid Pleocytosis
Author(s) -
Lise E. Nigrovic,
Vincent W. Chiang
Publication year - 2000
Publication title -
archives of pediatrics and adolescent medicine
Language(s) - English
Resource type - Journals
eISSN - 1538-3628
pISSN - 1072-4710
DOI - 10.1001/archpedi.154.8.817
Subject(s) - csf pleocytosis , medicine , aseptic meningitis , pleocytosis , enterovirus , cerebrospinal fluid , pediatrics , leukocytosis , meningitis , viral meningitis , gastroenterology , immunology , bacterial meningitis , virus
Infants with fever and cerebrospinal fluid (CSF) pleocytosis are routinely admitted to the hospital for parenteral antibiotic therapy for potential bacterial meningitis pending results of CSF culture. Published estimates suggest that 90% of all episodes of meningitis are caused by enterovirus. Enteroviral polymerase chain reaction (ePCR) has a sensitivity of 92% to 100% and a specificity of 97% to 100% in CSF.
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