Open AccessAbnormal Mesenchymal Differentiation in the Superior Semicircular Canal of Brn4/Pou3f4 Knockout Mice
Author(s) -
Steven E. Sobol,
Xiuyin Teng,
E. Bryan Crenshaw
Publication year - 2005
Publication title -
archives of otolaryngology - head and neck surgery
Language(s) - English
Resource type - Journals
eISSN - 1538-361X
pISSN - 0886-4470
DOI - 10.1001/archotol.131.1.41
Subject(s) - knockout mouse , mutant , biology , mesenchymal stem cell , semicircular canal , genetically modified mouse , gene knockout , inner ear , anatomy , phenotype , pathology , microbiology and biotechnology , endocrinology , medicine , transgene , genetics , gene , neuroscience , vestibular system
To examine the developmental time course of the mutant phenotype and cellular mechanisms that result in malformations of the superior semicircular canal (SSCC) in Brn4 knockout mice. Mutations in the Brn4/Pou3f4 gene result in characteristic inner ear abnormalities in mutant mouse pedigrees, and the findings in these mice are similar to those in human X-linked deafness type III.
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