Open AccessExpression of Vascular Endothelial Growth Factor Receptors on Tumor Cells in Head and Neck Squamous Cell Carcinoma
Author(s) -
Rajesh V. Lalla,
David S. Boisoneau,
Jeffrey D. Spiro,
Donald L. Kreutzer
Publication year - 2003
Publication title -
archives of otolaryngology--head and neck surgery
Language(s) - English
Resource type - Journals
eISSN - 1538-361X
pISSN - 0886-4470
DOI - 10.1001/archotol.129.8.882
Subject(s) - head and neck squamous cell carcinoma , autocrine signalling , angiogenesis , vascular endothelial growth factor , cancer research , biology , pathology , receptor , cell culture , cancer , medicine , head and neck cancer , vegf receptors , biochemistry , genetics
Angiogenesis is essential for the growth of solid tumors, including head and neck squamous cell carcinoma (HNSCC). Angiogenesis is regulated by angiogenic factors such as vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFRs) 1, 2, and 3 known to be located on vascular endothelial cells (VECs). We hypothesize that VEGFRs are also expressed on HNSCC tumor cells in vitro and in vivo and likely control tumor function in vivo.