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Individual Monitoring of Aspirin Desensitization
Author(s) -
Jan Gosepath,
Dirk J. Schaefer,
Ronald G. Amedee,
Wolf J. Mann
Publication year - 2001
Publication title -
archives of otolaryngology - head and neck surgery
Language(s) - English
Resource type - Journals
eISSN - 1538-361X
pISSN - 0886-4470
DOI - 10.1001/archotol.127.3.316
Subject(s) - aspirin , medicine , desensitization (medicine) , asthma , eicosanoid , gastroenterology , sinusitis , anesthesia , immunology , receptor , biology , biochemistry , arachidonic acid , enzyme
Patients with aspirin-sensitive rhinosinusitis, which is frequently associated with intrinsic bronchial asthma, can be desensitized by long-term treatment with oral aspirin. The exact mechanisms of this desensitization remain obscure, but modulations of the eicosanoid pathway occur and can be monitored with the help of a practicable in vitro assay on mixed leukocyte cultures.

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