Open AccessImmunolocalization of Activated Transforming Growth Factor β1 in Juvenile Nasopharyngeal Angiofibroma
Author(s) -
David G. Dillard,
Cynthia Cohen,
Susan Müller,
John Del Gaudio,
Owen Reichman,
Beryl Parrish,
David Rackley,
Anthony A. Gal
Publication year - 2000
Publication title -
archives of otolaryngology--head and neck surgery
Language(s) - English
Resource type - Journals
eISSN - 1538-361X
pISSN - 0886-4470
DOI - 10.1001/archotol.126.6.723
Subject(s) - stromal cell , juvenile nasopharyngeal angiofibroma , angiogenesis , transforming growth factor , biology , immunohistochemistry , pathology , growth factor , basic fibroblast growth factor , staining , vascular endothelial growth factor , cancer research , microbiology and biotechnology , receptor , immunology , medicine , biochemistry , radiology , vegf receptors
Juvenile nasopharyngeal angiofibroma (JNA) is a histologically benign, locally aggressive neoplasm of the nasopharynx that exclusively affects male adolescents. It is known to be sensitive to androgens, but there are likely intermediary cytokines and/or growth factors that mediate aggressive stromal cell proliferation and angiogenesis. Transforming growth factor beta1 (TGF-beta1) is a polypeptide that is secreted in an inactive form, cleaved to produce an active form, and then deactivated in the tissues. It activates fibroblast proliferation and is known to induce angiogenesis.