Localization of Inflammatory Mediators in Pediatric Sinus Mucosa | Zendy

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Localization of Inflammatory Mediators in Pediatric Sinus Mucosa

Author(s) -

Remy Mimms

Publication year - 2012

Publication title -

archives of otolaryngology - head and neck surgery

Language(s) - English

Resource type - Journals

eISSN - 1538-361X

pISSN - 0886-4470

DOI - 10.1001/archoto.2012.155

Subject(s) - cxcl13 , serpin , chemokine , biology , pathology , immunology , medicine , inflammation , chemokine receptor , biochemistry , gene

Microarray analyses of sinus mucosa in pediatric patients with chronic rhinosinusitis (CRS) have recently demonstrated increased messenger RNA expression of the inflammatory chemokines CXCL5 and CXCL13 and of the innate immune mediators β-defensin 1 (DEFB1), serum amyloid A2 (SAA2), and serpin B4. The objectives of this study were to determine whether these gene products were expressed at the protein level in pediatric sinus mucosa and to determine their localization.

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