Sensitization of Head and Neck Cancer to Cisplatin Through the Use of a Novel Curcumin Analog | Zendy

Waleed M. Abuzeid | Zendy; Samantha Davis | Zendy; Alice Tang | Zendy; Lindsay Saunders | Zendy; J. Chadwick Brenner | Zendy; Jiayuh Lin | Zendy; James R. Fuchs | Zendy; Emily Light | Zendy; Carol R. Bradford | Zendy; Mark E. Prince | Zendy; Thomas E. Carey | Zendy

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Sensitization of Head and Neck Cancer to Cisplatin Through the Use of a Novel Curcumin Analog

Author(s) -

Waleed M. Abuzeid,

Samantha Davis,

Alice Tang,

Lindsay Saunders,

J. Chadwick Brenner,

Jiayuh Lin,

James R. Fuchs,

Emily Light,

Carol R. Bradford,

Mark E. Prince,

Thomas E. Carey

Publication year - 2011

Publication title -

archives of otolaryngology - head and neck surgery

Language(s) - English

Resource type - Journals

eISSN - 1538-361X

pISSN - 0886-4470

DOI - 10.1001/archoto.2011.63

Subject(s) - cisplatin , stat3 , apoptosis , cancer research , curcumin , chemistry , cell culture , cancer cell , head and neck squamous cell carcinoma , sensitization , cancer , head and neck cancer , medicine , biology , immunology , chemotherapy , biochemistry , genetics

To determine whether a novel small molecule inhibitor derived from curcumin (FLLL32) that targets signal transducer and activator of transcription (STAT) 3 would induce cytotoxic effects in STAT3-dependent head and neck squamous cell cancer (HNSCC) cells and would sensitize tumors to cisplatin.

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