Estrogen-Mediated Angiogenesis in Thyroid Tumor Microenvironment Is Mediated Through VEGF Signaling Pathways
Author(s) -
Ameet Kamat,
Shilpi Rajoria,
Andrea L. George,
Robert Suriano,
Arul Shanmugam,
Uchechukwu C. Megwalu,
Pradeep Bangalore Prakash,
Raj K. Tiwari,
Stimson Schantz
Publication year - 2011
Publication title -
archives of otolaryngology - head and neck surgery
Language(s) - English
Resource type - Journals
eISSN - 1538-361X
pISSN - 0886-4470
DOI - 10.1001/archoto.2011.194
Subject(s) - fulvestrant , cancer research , angiogenesis , estrogen receptor , estrogen , endocrinology , thyroid cancer , follicular thyroid cancer , medicine , thyroid , biology , chemistry , papillary thyroid cancer , cancer , breast cancer
To explore the induction of a proangiogenic phenotype in endothelial cells in the thyroid tumor microenvironment by estrogen-treated thyroid cancer cells and to define the role of vascular endothelial growth factor (VEGF) in this interaction.
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