Genetic Alterations in Papillary Thyroid Carcinoma and Hashimoto Thyroiditis | Zendy

M Royer | Zendy; Haihong Zhang | Zendy; Chun-Yang Fan | Zendy; Mimi S. Kokoska | Zendy

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Genetic Alterations in Papillary Thyroid Carcinoma and Hashimoto Thyroiditis

Author(s) -

M Royer,

Haihong Zhang,

Chun-Yang Fan,

Mimi S. Kokoska

Publication year - 2010

Publication title -

archives of otolaryngology - head and neck surgery

Language(s) - English

Resource type - Journals

eISSN - 1538-361X

pISSN - 0886-4470

DOI - 10.1001/archoto.2010.20

Subject(s) - thyroiditis , goiter , pathology , thyroid carcinoma , laser capture microdissection , thyroid , thyroidectomy , medicine , microdissection , gastroenterology , biology , gene , genetics , gene expression

To determine the relationship between hOGG1 loss of heterozygosity (LOH), Hashimoto thyroiditis (HT), and papillary thyroid cancer (PTC). Hashimoto thyroiditis is an autoimmune mediated chronic inflammatory disease previously shown to coexist with papillary PTC. To further define the relationship between HT and PTC, we report an analysis of hOGG1, a major repair gene for free radical-induced oxidative DNA damages, in thyroidectomy specimens.

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