Skin Graft Take Rates, Granulation, and Epithelialization | Zendy

Emre Vural | Zendy; Maaike Berbée | Zendy; Alison A. Acott | Zendy; Ross Blagg | Zendy; ChunYang Fan | Zendy; Martin HauerJensen | Zendy

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Skin Graft Take Rates, Granulation, and Epithelialization

Author(s) -

Emre Vural,

Maaike Berbée,

Alison A. Acott,

Ross Blagg,

ChunYang Fan,

Martin HauerJensen

Publication year - 2010

Publication title -

archives of otolaryngology - head and neck surgery

Language(s) - English

Resource type - Journals

eISSN - 1538-361X

pISSN - 0886-4470

DOI - 10.1001/archoto.2010.103

Subject(s) - granulation tissue , angiogenesis , vascular endothelial growth factor , medicine , hypoxia (environmental) , skin grafting , revascularization , pathology , vegf receptors , immunology , wound healing , surgery , chemistry , cancer research , oxygen , myocardial infarction , organic chemistry

To compare the "take" rates of skin grafts between myeloid-selective hypoxia-inducible factor (HIF) 1alpha knockout (KO) and wild-type (WT) mice. Production of the alpha subunit of HIF-1alpha is increased in healing wounds, which stimulates expression of vascular endothelial growth factor (VEGF) to promote angiogenesis. Therefore, the take rate of skin grafts may be closely associated with the presence or absence of HIF-1alpha production in the recipient bed.

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