Inhibition of the Growth of Papillary Thyroid Carcinoma Cells by CI-1040 | Zendy

Ying C. Henderson | Zendy; SoonHyun Ahn | Zendy; Gary L. Clayman | Zendy

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Inhibition of the Growth of Papillary Thyroid Carcinoma Cells by CI-1040

Author(s) -

Ying C. Henderson,

SoonHyun Ahn,

Gary L. Clayman

Publication year - 2009

Publication title -

archives of otolaryngology - head and neck surgery

Language(s) - English

Resource type - Journals

eISSN - 1538-361X

pISSN - 0886-4470

DOI - 10.1001/archoto.2009.17

Subject(s) - cell growth , cancer research , in vivo , thyroid carcinoma , kinase , thyroid cancer , microbiology and biotechnology , in vitro , apoptosis , signal transduction , biology , chemistry , endocrinology , thyroid , medicine , biochemistry , genetics

Papillary thyroid carcinoma (PTC), the most common type of thyroid malignancy, usually possesses mutations, either RET/PTC rearrangement or BRAF mutation. Both mutations can activate the mitogen-activated protein kinase kinase/extracellular signal-related kinase signaling transduction pathway, which results in activation of transcription factors that regulate cellular proliferation, differentiation, and apoptosis.

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