Open AccessGene Expression Differences in Infected and Noninfected Middle Ear Complementary DNA Libraries
Author(s) -
Joseph E. Kerschner,
Edward Horsey,
Azad Ahmed,
Christy B. Erbe,
Pawjai Khampang,
Joseph A. Cioffi,
Fang Hu,
J. Christopher Post,
Garth D. Ehrlich
Publication year - 2009
Publication title -
archives of otolaryngology--head and neck surgery
Language(s) - English
Resource type - Journals
eISSN - 1538-361X
pISSN - 0886-4470
DOI - 10.1001/archoto.2008.513
Subject(s) - biology , gene , cdna library , complementary dna , downregulation and upregulation , calcium binding protein , slpi , gene expression , s100a8 , microbiology and biotechnology , genetics , immunology , inflammation , calcium , medicine
To investigate genetic differences in middle ear mucosa (MEM) with nontypeable Haemophilus influenzae (NTHi) infection. Genetic upregulation and downregulation occurs in MEM during otitis media (OM) pathogenesis. A comprehensive assessment of these genetic differences using the techniques of complementary DNA (cDNA) library creation has not been performed.