Open AccessDevelopment of an Adenoviral Vaccine Against E6 and E7 Oncoproteins to Prevent Growth of Human Papillomavirus–Positive Cancer
Author(s) -
Dong Hoon Lee,
Mary E. Anderson,
Shu Wu,
John H. Lee
Publication year - 2008
Publication title -
archives of otolaryngology--head and neck surgery
Language(s) - English
Resource type - Journals
eISSN - 1538-361X
pISSN - 0886-4470
DOI - 10.1001/archoto.2008.507
Subject(s) - in vivo , immune system , immunization , interferon gamma , interferon , viral vector , cancer research , medicine , virology , immunology , biology , recombinant dna , biochemistry , microbiology and biotechnology , gene
To test whether an immunization strategy that targets the E6 and E7 oncoproteins (E6/E7) may be an effective means to prevent the development of human papillomavirus (HPV)-positive head and neck squamous cell cancers using an in vivo mouse model and to determine whether such a response would prevent the establishment of viral transformed cells in vivo.