Development of an Adenoviral Vaccine Against E6 and E7 Oncoproteins to Prevent Growth of Human Papillomavirus–Positive Cancer | Zendy

Dong Wook Lee | Zendy; Mary E. Anderson | Zendy; Shu Wu | Zendy; John H. Lee | Zendy

Open Access

Development of an Adenoviral Vaccine Against E6 and E7 Oncoproteins to Prevent Growth of Human Papillomavirus–Positive Cancer

Author(s) -

Dong Wook Lee,

Mary E. Anderson,

Shu Wu,

John H. Lee

Publication year - 2008

Publication title -

archives of otolaryngology - head and neck surgery

Language(s) - English

Resource type - Journals

eISSN - 1538-361X

pISSN - 0886-4470

DOI - 10.1001/archoto.2008.507

Subject(s) - in vivo , immune system , immunization , interferon gamma , interferon , viral vector , cancer research , medicine , virology , immunology , biology , recombinant dna , biochemistry , microbiology and biotechnology , gene

To test whether an immunization strategy that targets the E6 and E7 oncoproteins (E6/E7) may be an effective means to prevent the development of human papillomavirus (HPV)-positive head and neck squamous cell cancers using an in vivo mouse model and to determine whether such a response would prevent the establishment of viral transformed cells in vivo.

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