Open AccessThe Effect of Proteasome Inhibition on p53 Degradation and Proliferation in Tonsil Epithelial Cells
Author(s) -
George F. Harris,
Mary E. Anderson,
John H. Lee
Publication year - 2008
Publication title -
archives of otolaryngology - head and neck surgery
Language(s) - English
Resource type - Journals
eISSN - 1538-361X
pISSN - 0886-4470
DOI - 10.1001/archoto.2007.37
Subject(s) - mg132 , growth inhibition , proteasome , proteasome inhibitor , cell growth , apoptosis , cell culture , in vivo , biology , bovine papillomavirus , in vitro , tonsil , microbiology and biotechnology , cancer research , immunology , biochemistry , genetics , genome , gene
To determine whether proteasome inhibition could reverse E6-mediated p53 degradation, cause selective growth inhibition, and induce apoptosis in human papillomavirus E6-transformed primary tonsil epithelial cells.
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