Spontaneous Regression of Small Melanocytic Choroidal Tumor

ondary lysosomes. It is unknown exactly how the impaired lysosomal function results in the clinical features, but it is likely that retained storage material in the retina along with other, yet-to-be– elucidated mechanisms results in widespread RPE dysfunction and photoreceptor death. In conclusion, the 2 patients presented herein and those described by Springer et al demonstrate that, in addition to corneal and lenticular opacity, retinal dystrophy may develop in patients with -mannosidosis. Consideration of retinal function, either through ERG or detailed fundus examination, is warranted prior to planning any surgical correction of corneal or lenticular opacity. Further study is required to determine the frequency with which it occurs and the rate of progression.