Genetic and Clinical Features of Progranulin-Associated Frontotemporal Lobar Degeneration | Zendy

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Genetic and Clinical Features of Progranulin-Associated Frontotemporal Lobar Degeneration

Author(s) -

Alice ChenPlotkin,

María Martínez-Lage,

Patrick Sleiman,

William T. Hu,

Robert A. Greene,

Elisabeth McCarty Wood,

Shaoxu Bing,

Murray Grossman,

Daniela Berg,

Kimmo J. Hatanpaa,

Myron Weiner,

Charles L. White,

William S. Brooks,

Glenda M. Halliday,

Jillian J. Kril,

Marla Gearing,

Thomas G. Beach,

Neill R. GraffRadford,

Dennis W. Dickson,

Rosa Rademakers,

Bradley F. Boeve,

Stuart PickeringBrown,

Julie S. Snowden,

John C. van Swieten,

Peter Heutink,

Harro Seelaar,

Jill R. Murrell,

Bernardino Ghetti,

Salvatore Spina,

Jordan Grafman,

Jeffrey Kaye,

Randall L. Woltjer,

Marsel Mesulam,

Eileen H. Bigio,

Albert Lladó,

Bruce L. Miller,

Ainhoa Alzualde,

Fermín Moreno,

Jonathan D. Rohrer,

Ian R. Mackenzie,

Howard Feldman,

Ronald L. Hamilton,

Marc Cruts,

Sebastiaan Engelborghs,

Peter Paul De Deyn,

Christine Van Broeckhoven,

Thomas D. Bird,

Nigel J. Cairns,

Alison Goate,

Matthew P. Frosch,

Peter Riederer,

Nenad Bogdanović,

Virginia M.Y. Lee,

John Q. Trojanowski,

Vivianna M. Van Deerlin

Publication year - 2011

Publication title -

archives of neurology

Language(s) - English

Resource type - Journals

eISSN - 1538-3687

pISSN - 0003-9942

DOI - 10.1001/archneurol.2011.53

Subject(s) - frontotemporal lobar degeneration , frontotemporal dementia , mutation , pathology , haplotype , medicine , biology , disease , genetics , dementia , gene , allele

To assess the relative frequency of unique mutations and their associated characteristics in 97 individuals with mutations in progranulin (GRN), an important cause of frontotemporal lobar degeneration (FTLD).

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