Association and Expression Analyses With Single-Nucleotide Polymorphisms in TOMM40 in Alzheimer Disease | Zendy

Carlos Cruchaga | Zendy; Petra Nowotny | Zendy; John S. K. Kauwe | Zendy; Perry G. Ridge | Zendy; Kevin H. Mayo | Zendy; Sarah Bertelsen | Zendy; Anthony L. Hinrichs | Zendy; Anne M. Fagan | Zendy; David M. Holtzman | Zendy; John C. Morris | Zendy; Alison Goate | Zendy

Open Access

Association and Expression Analyses With Single-Nucleotide Polymorphisms in <emph type="ital">TOMM40</emph> in Alzheimer Disease

Author(s) -

Carlos Cruchaga,

Petra Nowotny,

John S. K. Kauwe,

Perry G. Ridge,

Kevin H. Mayo,

Sarah Bertelsen,

Anthony L. Hinrichs,

Anne M. Fagan,

David M. Holtzman,

John C. Morris,

Alison Goate

Publication year - 2011

Publication title -

archives of neurology

Language(s) - English

Resource type - Journals

eISSN - 1538-3687

pISSN - 0003-9942

DOI - 10.1001/archneurol.2011.155

Subject(s) - apolipoprotein e , linkage disequilibrium , genotype , allele , single nucleotide polymorphism , alzheimer's disease , genetic association , biology , genetics , haplotype , age of onset , disease , medicine , allele frequency , gene

Apolipoprotein E (APOE) is the most statistically significant genetic risk factor for late-onset Alzheimer disease (LOAD). The linkage disequilibrium pattern around the APOE gene has made it difficult to determine whether all the association signal is derived from APOE or whether there is an independent signal from a nearby gene.

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