Open AccessAssociation of Long ATXN2 CAG Repeat Sizes With Increased Risk of Amyotrophic Lateral Sclerosis
Author(s) -
Hussein Daoud,
Véronique Belzil,
Sandra Martins,
Mike Sabbagh,
Pierre Provencher,
Lucette Lacomblez,
Vincent Meininger,
William Camu,
Nicolas Dupré,
Patrick A. Dion,
Guy A. Rouleau
Publication year - 2011
Publication title -
archives of neurology
Language(s) - English
Resource type - Journals
eISSN - 1538-3687
pISSN - 0003-9942
DOI - 10.1001/archneurol.2011.111
Subject(s) - amyotrophic lateral sclerosis , spinocerebellar ataxia , allele , genetics , medicine , gene , cohort , biology , disease
To analyze the ataxin 2 (ATXN2) CAG repeat size in a cohort of patients with amyotrophic lateral sclerosis (ALS) and healthy controls. Large (CAG)(n) alleles of the ATXN2 gene (27-33 repeats) were recently reported to be associated with an increased risk of ALS.
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