Open AccessTDP-43 in Cerebrospinal Fluid of Patients With Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
Author(s) -
Petra Steinacker,
Corinna Hendrich,
Anne D. Sperfeld,
Sarah Jesse,
Christine A. F. Von Arnim,
Stefan Lehnert,
Alice Pabst,
Ingo Uttner,
Hayrettin Tumani,
Virginia M.Y. Lee,
John Q. Trojanowski,
Hans A. Kretzschmar,
Albert C. Ludolph,
Manuela Neumann,
Markus Otto
Publication year - 2008
Publication title -
archives of neurology
Language(s) - English
Resource type - Journals
eISSN - 1538-3687
pISSN - 0003-9942
DOI - 10.1001/archneur.65.11.1481
Subject(s) - frontotemporal lobar degeneration , amyotrophic lateral sclerosis , cerebrospinal fluid , pathology , frontotemporal dementia , antibody , differential diagnosis , medicine , dementia , immunology , disease
Recently, TAR DNA-binding protein 43 (TDP-43) was identified as the major component of ubiquitin-positive tau-negative neuronal and glial inclusions in the most common form of frontotemporal lobar degeneration (FTLD) and in amyotrophic lateral sclerosis (ALS). It was demonstrated that different TDP-43 profiles correspond to clinical phenotypes of FTLD or ALS subgroups, and the differential diagnostic potential of TDP-43 was suggested.