Open AccessAssociation of GSK3B With Alzheimer Disease and Frontotemporal Dementia
Author(s) -
Barbara Schaffer,
Lars Bertram,
Bruce L. Miller,
Kristina Mullin,
Sandra Weıntraub,
Nancy Johnson,
Eileen H. Bigio,
Marsel Mesulam,
Martina WiedauPazos,
George R. Jackson,
Jeffrey L. Cummings,
Rita M. Cantor,
Aĺlan I. Levey,
Rudolph E. Tanzi,
Daniel H. Geschwind
Publication year - 2008
Publication title -
archives of neurology
Language(s) - English
Resource type - Journals
eISSN - 1538-3687
pISSN - 0003-9942
DOI - 10.1001/archneur.65.10.1368
Subject(s) - frontotemporal dementia , dementia , primary progressive aphasia , alzheimer's disease , genetics , medicine , disease , case control study , oncology , biology
Deposits of abnormally hyperphosphorylated tau are a hallmark of several dementias, including Alzheimer disease (AD), and about 10% of familial frontotemporal dementia (FTD) cases are caused by mutations in the tau gene. As a known tau kinase, GSK3B is a promising candidate gene in the remaining cases of FTD and in AD, for which tau mutations have not been found.