Open AccessRandomized, Double-blind, Placebo-Controlled Trial on Symptomatic Effects of Coenzyme Q10 in Parkinson Disease
Author(s) -
Alexander Storch
Publication year - 2007
Publication title -
archives of neurology
Language(s) - English
Resource type - Journals
eISSN - 1538-3687
pISSN - 0003-9942
DOI - 10.1001/archneur.64.7.nct60005
Subject(s) - levodopa , parkinson's disease , placebo , medicine , coenzyme q10 , randomized controlled trial , rating scale , physical therapy , restless legs syndrome , psychology , disease , psychiatry , pathology , neurology , developmental psychology , alternative medicine
Major hallmarks in the pathophysiology of Parkinson disease are cellular energy depletion and oxidative stress leading to cellular dysfunction and death. Coenzyme Q(10) (CoQ(10)) is an electron acceptor bridging mitochondrial complexes I and II/III and a potent antioxidant that consistently partially recovers the function of dopaminergic neurons.
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