Open AccessMitochondria in Parkinson Disease
Author(s) -
Miratul M. K. Muqit,
Sonia Gandhi,
Nicholas Wood
Publication year - 2006
Publication title -
archives of neurology
Language(s) - English
Resource type - Journals
eISSN - 1538-3687
pISSN - 0003-9942
DOI - 10.1001/archneur.63.5.649
Subject(s) - parkinson's disease , disease , mitochondrion , pathogenesis , medicine , mitochondrial disease , neuroscience , bioinformatics , mitochondrial dna , biology , pathology , genetics , gene
Parkinson disease is a devastating neurodegenerative disorder with no known cure. Impairment in mitochondrial dysfunction is thought to play a major role in the pathogenesis. Recent genetic advances suggest that mitochondrial dysfunction may be the primary defect. Drugs that target the mitochondria may therefore represent the best hope for disease-modifying therapies in Parkinson disease.
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