Case-Control Study of the Parkin Gene in Early-Onset Parkinson Disease | Zendy

Lorraine N. Clark | Zendy; Shehla Afridi | Zendy; Eric Karlins | Zendy; Yuanjia Wang | Zendy; Helen MejiaSantana | Zendy; Juliette Harris | Zendy; Elan D. Louis | Zendy; Lucien Côté | Zendy; Howard Andrews | Zendy; Stanley Fahn | Zendy; Cheryl Waters | Zendy; Blair Ford | Zendy; Steven J. Frucht | Zendy; Ruth Ottman | Zendy; Karen Marder | Zendy

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Case-Control Study of the Parkin Gene in Early-Onset Parkinson Disease

Author(s) -

Lorraine N. Clark,

Shehla Afridi,

Eric Karlins,

Yuanjia Wang,

Helen MejiaSantana,

Juliette Harris,

Elan D. Louis,

Lucien Côté,

Howard Andrews,

Stanley Fahn,

Cheryl Waters,

Blair Ford,

Steven J. Frucht,

Ruth Ottman,

Karen Marder

Publication year - 2006

Publication title -

archives of neurology

Language(s) - English

Resource type - Journals

eISSN - 1538-3687

pISSN - 0003-9942

DOI - 10.1001/archneur.63.4.548

Subject(s) - parkin , exon , compound heterozygosity , genetics , heterozygote advantage , mutation , biology , parkinson's disease , mutation frequency , gene , disease , medicine , allele

Mutations in parkin are estimated to account for as much as 50% of familial Parkinson disease (PD) and 18% of sporadic PD. Single heterozygous mutations in parkin in both familial and sporadic cases may also increase susceptibility to PD. To our knowledge, all previous studies have been restricted to PD cases; this is the first study to systematically screen the parkin coding regions and exon deletions and duplications in controls.

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