A Randomized Controlled Trial of Etilevodopa in Patients With Parkinson Disease Who Have Motor Fluctuations | Zendy

Karen Blindauer | Zendy; Ira Shoulson | Zendy; David Oakes | Zendy; Karl Kieburtz | Zendy; Steven Schwid | Zendy; Stanley Fahn | Zendy; Matthew Stern | Zendy; Christopher G. Goetz | Zendy; John G. Nutt | Zendy; Sari Goren | Zendy; N. Sayag | Zendy; M. Scolnik | Zendy; R. Levy | Zendy; Eli Eyal | Zendy; Phyllis Salzman | Zendy; Mary Pagano | Zendy

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A Randomized Controlled Trial of Etilevodopa in Patients With Parkinson Disease Who Have Motor Fluctuations

Author(s) -

Karen Blindauer,

Ira Shoulson,

David Oakes,

Karl Kieburtz,

Steven Schwid,

Stanley Fahn,

Matthew Stern,

Christopher G. Goetz,

John G. Nutt,

Sari Goren,

N. Sayag,

M. Scolnik,

R. Levy,

Eli Eyal,

Phyllis Salzman,

Mary Pagano

Publication year - 2006

Publication title -

archives of neurology

Language(s) - English

Resource type - Journals

eISSN - 1538-3687

pISSN - 0003-9942

DOI - 10.1001/archneur.63.2.210

Subject(s) - carbidopa , levodopa , gastric emptying , tolerability , parkinson's disease , medicine , randomized controlled trial , dosing , anesthesia , adverse effect , stomach , disease

Motor fluctuations are a common complication in patients with Parkinson disease (PD) receiving long-term levodopa therapy. Slowed gastric emptying and poor solubility of levodopa in the gastrointestinal tract may delay the onset of drug benefit after dosing. Etilevodopa is an ethyl-ester prodrug of levodopa that has greater gastric solubility, passes quickly into the small intestine, is rapidly hydrolyzed to levodopa, and has a shortened time to maximum levodopa concentration.

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